Test Details
Methodology
Ion-selective electrode (ISE); flame photometer
Result Turnaround Time
Within 1 day
Use
Electrolyte, acid-base balance; water balance; water intoxication; diagnose dehydration.
Hypernatremia occurs in dehydration. For instance, nasogastric protein feeding with insufficient fluids may cause hypernatremia. Hypernatremia without obvious cause may relate to Cushing syndrome, central or nephrogenic diabetes insipidus with insufficient fluids, primary aldosteronism, and other diseases. Severe hypernatremia may be associated with volume contraction, lactic acidosis, azotemia, weight loss, and increased hematocrit as evidence of dehydration. The corrected serum sodium is often high in nonketotic hyperosmolar coma. (A corrected Na+ is calculated by increasing Na+ by 1.3−1.6 mmol/L for each 100 mg/dL increment in serum or plasma glucose). 100 mg equals 5.56 mmol/L. The corrected serum sodium level calculated in nonketotic hyperosmolar coma: apparent mild hyponatremia with very high glucose may actually mean (corrected) hypernatremia.1
Hyponatremia occurs with nephrotic syndrome, cachexia, hypoproteinemia, intravenous glucose infusion, in congestive heart failure, and other clinical entities. Serum sodium is a predictor of cardiovascular mortality in patients in severe congestive heart failure.2
Hyponatremia without congestive failure or dehydration may occur with hypothyroidism, the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), renal failure, or renal sodium loss.
The differential diagnosis of hyponatremia includes Addison disease, hypopituitarism, liver disease including cirrhosis, hypertriglyceridemia, and psychogenic polydipsia. Diuretics and other drugs may cause hyponatremia. Sodium decreasing to levels <115 mmol/L can lead to significant neurological dysfunction with cerebral edema and increased intracranial pressure.
The differential diagnosis of hyponatremia includes determination of urine sodium and osmolality and serum urea nitrogen (BUN). BUN is often decreased in SIADH.
Specimen Requirements
Custom Additional Information
The ratio of serum sodium:osmolality is normally 0.43−0.50; a decreased ratio is found in uremia and other states in which there are increased substances with osmotic activity.
See Urea Nitrogen [001040], regarding hyponatremia with sodium <128 mmol/L, hypo-osmolality, low BUN and the syndrome of inappropriate secretion of antidiuretic hormone.
A number of situations result in “pseudohyponatremia.” In these circumstances treatment may be undesirable. With pseudohyponatremia serum sodium is decreased but the serum is not hypotonic (serum osmolality is normal or even increased). This may occur as the result of other molecules replacing water in relation to sodium. The water content is effectively lowered − sodium is “diluted.” In severe hypertriglyceridemia or paraprotein-related marked increase in protein, the concentration of sodium in relation to water is normal but the analytic result is determined as mmol/L of serum. Osmolality in this situation is determined as amount of particles per kg of water and will be normal. It has been shown that analyses by sodium electrode of the direct potentiometric type (requires no dilution) are not artifactually low in patients with hyperlipidemia.3 If large amounts of solute such as glucose or mannitol are present, movement of intracellular water into the extracellular space may produce dilutional hyponatremia. In this case sodium concentration in relation to water is actually low. “Osmolal gap” however exists between measured and calculated serum osmolality. Other substances capable of increasing serum osmolality (eg, ethanol) may also cause increase in the osmolal gap. Yet another cause of pseudohyponatremia is increased serum viscosity due to increased globulin proteins, occurring particularly in Waldenström macroglobulinemia. The sodium analyzer may aspirate too little sample when viscosity is so increased, leading to a factitious low sodium concentration. See discussion of “pseudohyponatremia” by Epstein and Osler.4
Hyponatremia may manifest lethal neurological complications (water intoxication with brain edema). Rapid correction of hyponatremia has been described5 but has also been implicated as a cause of demyelination.6
Hypernatremia may complicate some cases of lactulose-treated portal-systemic encephalopathy.7
Drug effects are summarized.8
Specimen
Serum (preferred) or plasma
Volume
1 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. Do not use oxalate, EDTA, or citrate plasma.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Gross hemolysis; improper labeling
Collection Instructions
Separate serum or plasma from cells within 45 minutes of collection. Label specimen as serum.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
134−144 mmol/L
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 001198 | Sodium | 2951-2 | 001198 | Sodium | mmol/L | 2951-2 |
| Order Code | 001198 | |||||
| Order Code Name | Sodium | |||||
| Order Loinc | 2951-2 | |||||
| Result Code | 001198 | |||||
| Result Code Name | Sodium | |||||
| UofM | mmol/L | |||||
| Result LOINC | 2951-2 |