Vedolizumab and Anti-Vedolizumab Antibody

CPT: 80299; 82397
Updated on 12/28/2018
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Test Details


  • Anti-integrin drug
  • Biological monitoring
  • Entyvio
  • Immunogenicity testing
  • Vedolizumab


Provides serum concentrations of vedolizumab and anti-vedolizumab antibodies in order to optimize treatment and facilitate clinical decision-making.


Drug half-life should be taken into consideration when interpreting concentrations measured in non-trough collections.


Electrochemiluminescence Immunoassay (ECLIA)

Additional Information

In the absence of anti-vedolizumab antibodies, the vedolizumab drug level reflects the total vedolizumab concentration. In the presence of anti-vedolizumab antibodies, the vedolizumab concentration reflects the antibody-unbound fraction of vedolizumab.

The presence of vedolizumab drug, even at concentrations well above target treatment levels , does not interfere with anti-vedolizumab antibody measurement. All positive anti-vedolizumab antibody results are verified by a confirmatory test.

Specimen Requirements


Serum or plasma


3 mL

Minimum Volume

1 mL


Serum-gel tube, red-top tube, or lavender top (EDTA) tube


Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum/plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x6

Causes for Rejection

Gross hemolysis; gross lipemia

Clinical Information


Rosario M, et al. Relationship between vedolizumab pharmacokinetics and endoscopic outcomes in patients with ulcerative colitis. Inflamm Bowel Dis. 2014;20:51-53.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504567 Vedolizumab and Anti-Vedo Ab 504568 Vedolizumab ug/mL 86898-4
504567 Vedolizumab and Anti-Vedo Ab 504569 Anti-Vedolizumab Antibody ng/mL 86899-2

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