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Monitor exposure to zinc; evaluate suspected nutritional inadequacy, especially in enteral or parental nutrition, critically ill or burn patients; cases of diabetes or delayed wound healing; growth retardation; follow therapy, for example when higher intravenous zinc doses are used to balance excessive ongoing GI losses in long-term total parenteral nutrition; follow oral zinc therapy in Wilson's disease; confirm acrodermatitis enteropathica and follow therapy
Levels may be low in fever, sepsis, estrogen therapy, stress, or myocardial infarction, reflecting mobilization from serum to the liver by interleukin. Levels are usually low in uremia with normal tissue levels. Levels may be high in familial hyperzincemia without toxicity or high zinc stores.
Inductively coupled plasma/mass spectrometry (ICP/MS)
Environmental exposure: 56−134 μg/dL
Chronic oral zinc supplementation interferes with copper absorption and may precipitate copper deficiency. Albumin is the primary zinc binding protein: zinc levels should be interpreted with awareness of serum albumin level.
Plasma (preferred) or serum
Separate serum from cells within 45 minutes of collection, and transfer to a certified metal-free transport tube (PeopleSoft N° 111166) for shipment to the laboratory. Plasma may be separated immediately and transferred to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|001800||Zinc, Plasma or Serum||5763-8||001800||Zinc, Plasma or Serum||ug/dL||5763-8|