Zinc, Serum or Plasma

CPT: 84630
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Test Details

Use

Monitor exposure to zinc; evaluate suspected nutritional inadequacy, especially in enteral or parental nutrition, critically ill or burn patients; cases of diabetes or delayed wound healing; growth retardation; follow therapy, for example when higher intravenous zinc doses are used to balance excessive ongoing GI losses in long-term total parenteral nutrition; follow oral zinc therapy in Wilson's disease; confirm acrodermatitis enteropathica and follow therapy

Limitations

Levels may be low in fever, sepsis, estrogen therapy, stress, or myocardial infarction, reflecting mobilization from serum to the liver by interleukin. Levels are usually low in uremia with normal tissue levels. Levels may be high in familial hyperzincemia without toxicity or high zinc stores.

Methodology

Inductively coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

Environmental exposure: 56−134 μg/dL

Additional Information

Chronic oral zinc supplementation interferes with copper absorption and may precipitate copper deficiency. Albumin is the primary zinc binding protein: zinc levels should be interpreted with awareness of serum albumin level.

Specimen Requirements

Specimen

Plasma (preferred) or serum

Volume

2 mL

Minimum Volume

0.6 mL

Container

Royal blue-top (EDTA) tube or royal blue-top tube without EDTA

Collection

Separate serum from cells within 45 minutes of collection, and transfer to a certified metal-free transport tube (PeopleSoft N° 111166) for shipment to the laboratory. Plasma may be separated immediately and transferred to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Certified metal-free plastic transport tube not submitted; unspun royal blue-top tube from which the plasma or serum has not been removed; gel-barrier tube

Clinical Information

References

Alfrey AC. Essential trace elements. In Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. 2nd ed. New York, NY: Raven Press Ltd;1992:2993-3003.
Ruz M, Cavan KR, Bettger WJ, et al. Development of a dietary model for the study of mild zinc deficiency in humans and evaluation of some biochemical and functional indices of zinc status. Am J Clin Nutr. 1991; 53(5):1295-1303.2021137

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001800 Zinc, Plasma or Serum 5763-8 001800 Zinc, Plasma or Serum ug/dL 5763-8

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