Valproic Acid, Free, Serum or Plasma

CPT: 80165
Print Share

Test Details

Synonyms

  • Depacon®
  • Depakene®
  • Depakote®
  • Free Valproic Acid
  • Stavzor™
  • Valproate

Use

Since valproic acid is highly bound, drugs that compete for protein binding sites can increase the amount of free valproic acid (biologically active protein); these include dicumarol, high dose salicylates, and phenylbutazone. If toxicity is suspected, a free valproic acid level should be obtained.

Methodology

Ultrafiltrate assayed by liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Therapeutic: 6.0-22.0 μg/mL

Specimen Requirements

Specimen

Serum or plasma

Volume

3 mL

Minimum Volume

1.1 mL

Container

Red-top tube or lavender-top (EDTA) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Collection

Transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gel-barrier tube; hemolysis; serum or plasma not removed from cells

Clinical Information

References

Jacobson SA. Laboratory Medicine in Psychiatry and Behavioral Science. Washington, DC: American Psychiatric Publishing; 2012:368.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070789 Free Valproic Acid (Depakote) 4087-3 070790 Free Valproic Acid (Depakote) ug/mL 4087-3
Reflex Table for Free Valproic Acid (Depakote)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 007000 See below: 007000 See below: N/A

For Providers

Please login to order a test.

 

© 2017  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf