Transferrin

CPT: 84466
Print Share

Test Details

Synonyms

  • Siderophilin

Use

Increased in iron deficiency anemia. It is decreased in chronic inflammatory states, hereditary atransferrinemia, some instances of acquired liver disease, neoplasia, and renal disease. Transferrin is an index of nutritional status.

Limitations

Increased in patients on oral contraceptives and in late pregnancy. May not be elevated in iron-deficient states in which there is severe protein malnutrition (eg, kwashiorkor).

Methodology

Immunologic

Reference Interval

200−370 mg/dL

Additional Information

Transferrin is responsible for 50% to 70% of the iron binding capacity of serum. Since other proteins may bind iron, transferrin is not the same as TIBC. Transferrin is an iron transport protein receiving and binding iron for delivery to receptors at recipient cells. The human transferrin gene, responsible for production of this single chain, 77 kilodalton polypeptide resides on chromosome 3, band q21-25. Transferrin has two iron-binding sites and is largely but not exclusively synthesized by the liver. There are over 20 genetic variants, largely single amino acid substitutions. Transferrin levels rise with iron deficiency and fall in cases of iron overload. Transferrin is normally only about one-third saturated and is responsible for circadian variation in serum iron (peak in AM) due to variable activity of the reticuloendothelial system. Recent studies have indicated that the serum transferrin receptor levels can be used as an index of iron deficiency anemia.

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

1 mL

Container

Gel-barrier tube, red-top tube, or green-top (heparin) tube; do not use EDTA plasma.

Patient Preparation

Fasting specimen is preferred.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004937 Transferrin 3034-6 004937 Transferrin mg/dL 3034-6

For Providers

Please login to order a test.

 

© 2019  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf