Serum Integrated 1

CPT: 84163
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Synonyms

  • Down Syndrome
  • PAPP-A

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (i.e. prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing provided from 10.0 to 14.0 weeks of gestation.


Expected Turnaround Time

2 - 5 days


Related Information


Related Documents


Specimen Requirements


Specimen

Serum


Volume

3 mL


Minimum Volume

1 mL


Container

Gel-barrier tube


Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type


Test Details


Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18


Limitations

Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Chemiluminescent immunoassay


References

Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467. 10441601

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017200 Serum Integrated 1 017864 Results N/A
017200 Serum Integrated 1 017201 Test Results: 49586-1
017200 Serum Integrated 1 017204 Submit Part 2 Sample Using N/A
017200 Serum Integrated 1 017205 Gestational Age weeks 18185-9
017200 Serum Integrated 1 017206 Gest. Age Based on 21299-3
017200 Serum Integrated 1 017207 Maternal Age at EDD yr 43993-5
017200 Serum Integrated 1 017208 Race 21484-1
017200 Serum Integrated 1 017209 Weight lbs 29463-7
017200 Serum Integrated 1 017291 Number of Fetuses 11878-6
017200 Serum Integrated 1 018219 PAPP-A Value ng/mL 48407-1
017200 Serum Integrated 1 017293 Comments: 77202-0
017200 Serum Integrated 1 017857 Note: N/A
017200 Serum Integrated 1 511933 PDF 11502-2

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