RB1 Oncology FISH

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Test Details


  • Leukemia FISH
  • Lymphoma FISH


Confirmation/identification of leukemia/lymphoma-related alterations; leukemia/lymphoma monitoring of residual disease, transplants, and indolent clones (see list or call lab for probe availability)


Fluorescence in situ hybridization (FISH)

Additional Information

Unique sequence DNA probe for deletion of the retinoblastoma (RB-1) gene region.

Specimen Requirements


Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA are also acceptable.


Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow


Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510374 RB1 Oncology FISH 510240 Specimen Type 31208-2
510374 RB1 Oncology FISH 510241 Cells Counted N/A
510374 RB1 Oncology FISH 510244 Cells Analyzed N/A
510374 RB1 Oncology FISH 510246 Interpretation 50398-7
510374 RB1 Oncology FISH 510372 Director Review: 48672-0
510374 RB1 Oncology FISH 510373 FISH Result 48674-6

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