pH, Urine

CPT: 83986
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Expected Turnaround Time

3 - 4 days


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Specimen Requirements


Specimen

Urine (random)


Volume

5 mL


Minimum Volume

1 mL


Container

Plastic urine container, no preservative


Collection

Freshly voided random urine


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Icteric samples; preservative added


Test Details


Use

The urine pH is a crude measure of the acid-base balance of the body. It may be helpful in determining subtle presence of distal renal tubular disease or pyelonephritis. Urine pH is useful for identifying crystals in urine and determining predisposition to form a given type of stone. See table.

pH, Urine

Conditions Associated With Acid Urine

Metabolic acidosis

Diabetes mellitus

Diarrhea

Starvation

Respiratory acidosis

Emphysema

Sleep

Renal failure with lack of NH3 buffer

Gastric suction and vomiting

Diuretic therapy

Postprandial alkaline tide (one hour after meal)

Fanconi syndrome and Milkman syndrome

(increased urinary loss of bicarbonate)

Alkali therapy (citrate, bicarbonate)

Conditions Associated With Alkaline Urine

Respiratory alkalosis

Metabolic alkalosis

Urea-splitting bacteria (Proteus sp)

Vegetable diet


Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Electrochemical (pH meter)


Reference Interval

Newborns: 5.0−7.0; thereafter: 4.5−8.0


Additional Information

Dietary factors affect urine pH. Alkaline urine is observed in persons who eat large quantities of citrus fruit and vegetables. Acid urine is observed with high meat intake. Pyridium® metabolites may mask the pH reaction. Urine pH >6.5 indicates presence of bicarbonate while pH <5.5 indicates absence of bicarbonate. Consistently acid urine, pH <5.5, is associated with xanthine, cystine, and uric acid stones. Calcium oxalate and apatite stones are not associated with any particular disturbance of urine pH. Alkaline urine pH >7 is associated with calcium carbonate, calcium phosphate, and especially magnesium ammonium phosphate stones. In conjunction with serum pH and bicarbonate levels urine pH may be applied to the study of renal tubular acidification.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
013037 pH, Urine 2756-5 013037 pH, Urine 2756-5

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