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Non-HDL Cholesterol Profile
- Non-HDL Cholesterol
Cholesterol, total; high-density lipoprotein (HDL) cholesterol; non-HDL cholesterol (calculation)
The third report of the National Cholesterol Education Program (NCEP) Expert Panel's revised guidelines1 for the treatment of cholesterol in adults called for increased attention to the metabolic syndrome and diabetes. These guidelines highlighted the increased inaccuracy of the LDL-C measurement in these patients because of elevated triglycerides. To overcome the inaccuracy of the calculated LDL-C method when triglycerides are elevated, measurement of non-high-density lipoprotein (non-LDL-C) was recommended as a better means to follow these patients toward their treatment goals. Non-HDL-C is a calculation (total cholesterol minus HDL-C), ie, the sum of the VLDL-C, LDL-C, and IDL-C. While LDL-C has long been the primary focus of cholesterol reduction efforts, researchers have identified several other lipoproteins that also affect cardiovascular health. The advantage of non-HDL-C measurement is that it accounts for cholesterol in the other potentially atherogenic lipoprotein particles, which include VLDL-C, IDL-C, LDL-C, and lipoprotein(a). Studies2,3 have shown that the measurement of non-HDL-C, rather than LDL-C, would be a better target for therapy, especially in persons with a triglyceride level >200 mg/dL. Cutpoints for non-HDL-C are 30 mg/dL higher than the LCL-C cutpoint (eg, if the patient's LDL-C goal is <160 mg/dL, the non-HDL-C goal should be <190 mg/dL).
See individual tests.
Separate serum from cells within 45 minutes of venipuncture. Lipid profiles are best avoided following acute myocardial infarct, for up to three months, although cholesterol can be measured in the first 24 hours.
Causes for Rejection
Improperly labeled specimen
State patient's age and sex on the test request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|344265||Non-HDL Cholesterol Panel||001065||Cholesterol, Total||mg/dL||2093-3|
|344265||Non-HDL Cholesterol Panel||011817||HDL Cholesterol||mg/dL||2085-9|
|344265||Non-HDL Cholesterol Panel||011976||Non-HDL Cholesterol||mg/dL||43396-1|
|344265||Non-HDL Cholesterol Panel||011824||Comment:||N/A|