Nickel, Urine

CPT: 82570; 83885
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Test Details


  • Ni, Urine

Test Includes

Creatinine, urine; nickel, urine; nickel:creatinine ratio; nickel, urine (24-hour)


Monitor exposure to nickel


Inductively-coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

Environmental exposure: 0.0−9.9 μg/g creatinine; 0.0−7.0 μg/24 hours

Occupational exposure (soluble compounds): 30 μg/g creatinine1

Specimen Requirements


Urine (random or 24-hour)


5 mL

Minimum Volume

1.5 mL


Plastic urine container, no preservative


Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Avoid contact with metal during collection. Screw the lid on securely.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

State 24-hour volume on the request form, if applicable. Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.


1. Lauwerys RR, Hoet P. Industrial Chemical Exposure: Guidelines for Biological Monitoring. 2nd ed. Boca Raton, FL: Lewis Publishers.1993:292.


Baselt RC. Biological Monitoring Methods for Industrial Chemicals. 2nd ed. Littleton, Mass: Yearbook Medical Publishers;1988.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071563 Nickel, Urine 071569 Nickel, Urine ug/L 14099-6
071563 Nickel, Urine 071572 Nickel, Urine (24hr) ug/24 hr 5705-9
071563 Nickel, Urine 723280 Creatinine(Crt),U g/L 2161-8
071563 Nickel, Urine 071570 Nickel/Creat. Ratio ug/g creat 13472-6

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