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Natural Killer Cell and Activated T-Cell Profile/IL-2r
- Interleukin-2 Receptor
- TAC Antigen
Percentage CD3+; absolute CD3+; percentage CD3+CD25+ (IL-2 receptor); absolute CD3+CD25+; percentage CD3-CD56+ (NK); total CD3-CD56+ (NK); CBC with differential; total lymphocyte count
Assess changes in T-lymphocyte surface markers that may indicate immune stimulation
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Reference intervals for adults have been established by the laboratory. See table.
95% Confidence Interval
Natural killer (NK) cells are large granular lymphocytes that mediate MHC-unrestricted cytotoxicity against virus-infected and malignant cells and manufacture a number of cytokines following stimulation of the immune system.
The combination of IL-2 and T-cell markers can be used to assess the state of activation of T cells. NK cells are responsible for the destruction of virally infected cells, tumor cells, and antibody-dependent cellular cytotoxicity.
Fill tube(s) to capacity.
Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the test request form.
Maintain specimen at room temperature.
Causes for Rejection
Hemolysis; specimen refrigerated or frozen; clotted specimen; contaminated specimen