Multiple Sclerosis (MS) Profile

CPT: 82040; 82042; 82784(x2); 83916
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Test Details


  • MS Profile

Test Includes

IgG and albumin quantitation in both serum and spinal fluid samples; CSF, IgG:CSF albumin ratio; CSF IgG index; CSF IgG synthesis rate; oligoclonal banding


Adjunct in aiding clinical diagnosis of multiple sclerosis


Oligoclonal banding: IEF; CSF IgG, CSF albumin, and serum IgG: immunologic; serum albumin: spectrophotometry; synthesis rate, ratio, and index by calculation

Specimen Requirements


Serum and cerebrospinal fluid (CSF), collected at the same time


2 mL serum and 1.5 mL CSF

Minimum Volume

0.8 mL serum and 0.6 mL CSF

Sample Requirements for Multiple Sclerosis Profile

Profile Components

CSF Preferred

CSF Minimum

Serum Preferred

Serum Minimum


*IgG synthesis rate and IgG:albumin ratio (CSF) within the multiple sclerosis profile utilize the same IgG and albumin (CSF and serum) results from the IgG index for calculations; therefore, no additional sample is required.

Oligoclonal banding

0.5 mL

0.1 mL

0.5 mL

0.1 mL

Serum and CSF must be collected at the same time.

IgG index*

1 mL

0.5 mL

1.5 mL

0.7 mL

Includes IgG and albumin on CSF and serum

Total sample required:

1.5 mL

0.6 mL

2.0 mL

0.8 mL


Transport tubes


Collect serum and CSF at the same time. Avoid contaminating CSF with blood. Centrifuge CSF at 1500xg for 20 minutes and place the supernatant into separate tubes. Ensure that residual fibrin and cellular matter have been removed.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Plasma instead of serum specimen; serum and CSF not collected within eight hours of each other


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123075 Multiple Sclerosis(MS) Profile 012212 IgG, Quant, CSF mg/dL 2464-6
123075 Multiple Sclerosis(MS) Profile 012230 Albumin, CSF mg/dL 1746-7
123075 Multiple Sclerosis(MS) Profile 001081 Albumin g/dL 1751-7
123075 Multiple Sclerosis(MS) Profile 001776 Immunoglobulin G, Qn, Serum mg/dL 2465-3
123075 Multiple Sclerosis(MS) Profile 160311 IgG/Alb Ratio, CSF 2470-3
123075 Multiple Sclerosis(MS) Profile 101124 CSF IgG Index 14117-6
123075 Multiple Sclerosis(MS) Profile 085937 IgG, Syn Rate,CSF mg/day 14116-8
123075 Multiple Sclerosis(MS) Profile 111237 Oligoclonal Bands N/A
123075 Multiple Sclerosis(MS) Profile 111666 Oligoclonal Bands 48668-8
123075 Multiple Sclerosis(MS) Profile 120173 CSF/Serum Alb. Index 1756-6

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at