Mitochondrial (M2) Antibody

CPT: 86381
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Synonyms

  • AMA

Expected Turnaround Time

2 - 3 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added


Test Details


Use

The presence of mitochondrial antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of primary biliary cirrhosis (PBC).


Limitations

The presence of immune complexes in the patient's sample may cause an increased level of nonspecific binding and produce false-positive results. Not all PBC patients are positive for mitochondrial antibodies. Results of this assay should be used in conjunction with clinical findings and other serologic tests.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


Reference Interval

• Negative: 0.0−20.0

• Equivocal: 20.1−24.9

• Positive: >24.9


Additional Information

Antimitochondrial antibodies (AMA) have been reported in 90% to 96% of patients with primary biliary cirrhosis. AMA are also occasionally found in sera of patients with other liver diseases, including chronic active hepatitis, cryptogenic cirrhosis, as well as in patients with clinical but no biochemical evidence of liver disease. The M2 antigen used is strongly associated with PBC, while other types (M1, M2, M5, and M6) are associated with a wide variety of conditions.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006650 Mitochondrial (M2) Antibody 14251-3 006652 Mitochondrial (M2) Antibody Units 14251-3

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