Methylmalonic Acid, Urine

CPT: 83921
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Test Details

Test Includes

Creatinine, urine; methylmalonic acid, urine

Use

Diagnose cobalamin (vitamin B12) deficiency

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

0.4−2.5 μmol/mmol crt

Specimen Requirements

Specimen

Urine (random)

Volume

5 mL

Minimum Volume

0.6 mL

Container

Plastic urine container, no preservative

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

19 days

Freeze/thaw cycles

Stable x3

Clinical Information

References

Matchar DB, Feussner JR, Millington DS, Wilkinson RH Jr, Watson DJ, Gale D. Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. Ann Intern Med. 1987 May; 106(5):707-710. 3551712
Specker BL, Miller D, Norman EJ, Greene H, Hayes KC. Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B12.Am J Clin Nutr. 1988 Jan, 47(1):89-92. 3337042
Stabler SP, Marcell PD, Podell ER, Allen RH, Lindenbaum J. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest. 1986 May, 77(5):1606-1612.3700655

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
716365 Methylmalonic Acid, Urine 716348 Methylmalonic Acid, U umol/L 32287-5
716365 Methylmalonic Acid, Urine 716445 MMA - Normalized umol/mmol cr 25116-5
716365 Methylmalonic Acid, Urine 723281 Creatinine(Crt), U g/L 2161-8

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf