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- Non-HDL Cholesterol
Cholesterol, total; high-density lipoprotein (HDL) cholesterol; low-density lipoprotein (LDL) cholesterol (calculation); nonhigh-density lipoprotein (non-HDL) cholesterol (calculation = total cholesterol minus HDLC); triglycerides; very low-density lipoprotein (VLDL) cholesterol (calculation)
The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel's revised guidelines1 for the treatment of cholesterol in adults called for increased attention to the metabolic syndrome and diabetes. These guidelines highlighted the increased inaccuracy of the LDL-C measurement in these patients because of elevated triglycerides. To overcome the inaccuracy of the calculated LDL-C method when triglycerides are elevated, measurement of nonhigh-density lipoprotein (non-HDL) was recommended as a better means to follow these patients toward their treatment goals. Non-HDL-C is a calculation (total cholesterol minus HDL-C), ie, the sum of the VLDL-C, LDL-C, and IDL-C. While LDL-C has long been the primary focus of cholesterol reduction efforts, researchers have identified several other lipoproteins that also affect cardiovascular health. The advantage of non-HDL-C measurement is that it accounts for cholesterol in the other potentially atherogenic lipoprotein particles, which include VLDL-C, IDL-C, LDL-C, and lipoprotein(a). Studies2,3 have shown that the measurement of non-HDL-C, rather than LDL-C, would be a better target for therapy, especially in persons with a triglyceride level >200 mg/dL. Cut-points for non-HDL-C are 30 mg/dL higher than the LCL-C cut-points (eg, if the patient's LDL-C goal is <160 mg/dL, the non-HDL-C goal should be <190 mg/dL).
LDL cholesterol cannot be calculated if triglyceride is >400 mg/dL.
See individual tests.
Separate serum from cells within 45 minutes of collection. Lipid panels are best avoided for up to three months following acute myocardial infarction, although cholesterol can be measured in the first 24 hours.
Maintain specimen at room temperature.
Causes for Rejection
Specimen with greatly elevated triglycerides (>400 mg/dL); improper specimen labeling
State patient's age and sex on the request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|343925||LP+Non-HDL Cholesterol||001065||Cholesterol, Total||mg/dL||2093-3|
|343925||LP+Non-HDL Cholesterol||011817||HDL Cholesterol||mg/dL||2085-9|
|343925||LP+Non-HDL Cholesterol||011916||VLDL Cholesterol Cal||mg/dL||13458-5|
|343925||LP+Non-HDL Cholesterol||011976||Non-HDL Cholesterol||mg/dL||43396-1|
|343925||LP+Non-HDL Cholesterol||012054||LDL Cholesterol Calc||mg/dL||13457-7|