Lipid Panel With Total Cholesterol:HDL Ratio

CPT: 80061
Print Share

Test Details

Test Includes

Lipid panel; total cholesterol:HDL ratio

Use

Evaluation of hyperlipidemia as an index to coronary artery disease. Investigation of serum lipids is indicated in those with coronary and other arterial disease, especially when it is premature, and in those with family history of atherosclerosis or of hyperlipidemia. In this sense, the expression “premature” is mostly used to include those younger than 40 years of age.

Limitations

Patients with obstructive liver disease may develop lipoprotein abnormalities. Serum lipid factors have not been demonstrated to have a strong influence on recurrent stenosis following coronary angioplasty, the pathogenesis of which is presently not well understood. Low-density lipoprotein cholesterol (LDL-C) cannot be calculated if triglyceride is >400 mg/dL.

Methodology

Enzymatic

Additional Information

Patients with xanthomas should be worked up with lipid panels, but not those with xanthelasmas or xanthofibromas in the sense of dermatofibromas. Those whose fasting serum is lipemic should have a lipid panel, but the serum of a subject with high cholesterol (but normal triglyceride) is not milky in appearance. The patient with high cholesterol (>240 mg/dL) should have a lipid panel. Patients with cholesterol levels between 200−240 mg/dL plus two other coronary heart disease risk factors should also have a lipid panel.1 In addition to application in screening programs for evaluation of risk factors for coronary arterial disease, lipid profiling may lead to detection of some cases of hypothyroidism.

Primary hyperlipoproteinemia includes hypercholesterolemia, a direct risk factor for coronary heart disease.

Secondary hyperlipoproteinemia includes nephrosis, renal failure, obesity, diabetes mellitus, alcoholism, primary biliary cirrhosis, and other types of cholestasis. Decreased lipids are found with some cases of malabsorption, malnutrition, and advanced liver disease. In abetalipoproteinemia, cholesterol is <70 mg/dL.

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

1 mL

Container

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube

Patient Preparation

Patient should be on a stable diet, ideally for two to three weeks prior to collection of blood, and should fast for 12 to 14 hours before collection of the specimen.

Collection

Separate serum or plasma from cells within 45 minutes of collection. Lipid panels are best avoided for three months following acute myocardial infarction, although cholesterol can be measured in the first 24 hours.

Storage Instructions

Room temperature; if arrival at lab will extend beyond three days, then refrigerate.

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Specimen with greatly elevated triglycerides (>400 mg/dL); improper specimen labeling

Clinical Information

Special Instructions

State the patient's age and sex on the test request form.

Footnotes

1. Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel. Arch Intern Med. 1988 Jan; 148(1):36-69.3422148

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
221010 Lipid Panel w/ Chol/HDL Ratio 001065 Cholesterol, Total mg/dL 2093-3
221010 Lipid Panel w/ Chol/HDL Ratio 001172 Triglycerides mg/dL 2571-8
221010 Lipid Panel w/ Chol/HDL Ratio 011817 HDL Cholesterol mg/dL 2085-9
221010 Lipid Panel w/ Chol/HDL Ratio 011916 VLDL Cholesterol Cal mg/dL 13458-5
221010 Lipid Panel w/ Chol/HDL Ratio 012054 LDL Cholesterol Calc mg/dL 13457-7
221010 Lipid Panel w/ Chol/HDL Ratio 011824 Comment: 77202-0
221010 Lipid Panel w/ Chol/HDL Ratio 100065 T. Chol/HDL Ratio ratio 9830-1

For Providers

Please login to order a test.

 

© 2018  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf