Legionella pneumophila Urinary Antigen

CPT: 87449
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Test Details

Use

Confirm the diagnosis of Legionella pneumophila serogroup 1 infection

Limitations

This test will not detect species or serogroups other than Legionella pneumophila serogroup 1.

Methodology

Enzyme immunoassay (EIA)

Reference Interval

No Legionella pneumophila serogroup 1 antigen detected

Additional Information

Legionella pneumophila has been estimated to cause 80% to 85% of Legionella infections, with serogroup 1 accounting for most of these. Current methods of diagnosis for Legionella infection include culture and DFA. All of these other tests require a high quality respiratory specimen to perform this test and, unfortunately, many patients with Legionella infection do not produce sputum. A number of investigators have shown that a specific soluble antigen was present in the urine of patients with Legionnaires' disease, which can be detected both early and late in the disease.

Specimen Requirements

Specimen

Urine

Volume

5 mL

Container

Sterile screw-cap container

Storage Instructions

Refrigerate.

Causes for Rejection

Swab specimen; inappropriate specimen transport device; unlabeled specimen or name discrepancy between specimen and request label; nonurine specimen

Clinical Information

References

Berdal PP, Farshy CE, Feelley JC. Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. J Clin Microbiol. 1979 May; 9(5):575-578. 383744
Kohler RB, Zimmerman SE, Wilson E, et al. Rapid immunoassay diagnosis of Legionnaires' disease: Detection and partial characterization of urinary antigen. Ann Intern Med. 1981 May; 94(5):601-605. 7235392
Reingold AL, Thomason BM, Brake BJ, Thacker L, Wilkinson HW, Kuritsky JN. Legionella pneumonia in the United States: The distribution of serogroups and species causing human illness. J Infect Dis. 1984 May; 149(5):819. 6726009

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
182246 L. pneumophila Serogp 1 Ur Ag 41499-5 182246 L. pneumophila Serogp 1 Ur Ag 41499-5

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