Lactic Acid Dehydrogenase (LD), Body Fluid

CPT: 83615
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Test Details

Synonyms

  • Lactate Dehydrogenase, Variable
  • LD Variable

Use

A fluid LD activity nearly equal to the plasma activity is usually associated with inflammatory processes

Methodology

Kinetic

Reference Interval

• Peritoneal: Not established

• Pleural:

− Transudate: <200 U/L

− Exudate: >200 U/L

• Synovial: <240 U/L

• CSF: Not established

The method performance specifications have not been established for this test in body fluid. The test result should be integrated into the clinical context for interpretation.

Additional Information

Lactate dehydrogenase (LD) is a normal component of CSF. Increased amounts may occur in association with ischemic necrosis, meningitis, leukemia, metastatic cancer of the CNS, and lymphoma. LDH1 and LDH2 are decreased in lavage fluid in pulmonary alveolar proteinosis.1 One application of LD measurement is the differential diagnosis of intracranial hemorrhage in neonates versus traumatic tap. Lactate dehydrogenase is elevated in proportion to severity of CNS hemorrhage, but unchanged by traumatic tap. CSF LDH is higher in stroke than in transient ischemic attack.2

Specimen Requirements

Specimen

Fluid or cerebrospinal fluid (CSF)

Volume

1 mL fluid or 1 mL CSF

Minimum Volume

0.3 mL

Container

Sterile body fluid container

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

7 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Improper labeling

Clinical Information

Footnotes

1. Hoffman RM, Rogers RM. Serum and lavage lactate dehydrogenase isoenzymes in pulmonary alveolar proteinosis. Am Rev Respir Dis. 1991 Jan; 143(1):42-46. 1986683
2. Lampl Y, Paniri Y, Eshel Y, Sarova-Pinhas I. Cerebrospinal fluid lactate dehydrogenase levels in early stroke and transient ischemic attacks. Stroke. 1990 Jun; 21(6):854-857. 2349587

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
100156 LD, Body Fluid 2529-6 100156 LD, Body Fluid IU/L 2529-6

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