Integrated 2

CPT: [MAAA: 81511] or 82105; 82677; 84702; 86336
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Test Details

Synonyms

  • AFP, Maternal
  • Down Syndrome

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Limitations

Integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

Methodology

Chemiluminescent immunoassay

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube, no thrombin additive

Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Clinical Information

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Patient must have submitted a previous specimen in the first trimester for the Integrated 1 test. Gestational age will be based on crown rump length provided with the first trimester specimen. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing is provided from 15.0 to 21.9 weeks of gestation.

References

Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467.10441601

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017170 Integrated 2 017865 Results N/A
017170 Integrated 2 017171 Test Results: 49586-1
017170 Integrated 2 017174 FIRST TRIMESTER SAMPLE N/A
017170 Integrated 2 017175 Crown Rump Length mm 11957-8
017170 Integrated 2 018058 Crown Rump Length Twin B mm 11957-8
017170 Integrated 2 017176 CRL Scan 34970-4
017170 Integrated 2 018059 CRL Scan Twin B 34970-4
017170 Integrated 2 018020 Sonographer ID# 49089-6
017170 Integrated 2 017177 Collected On 33882-2
017170 Integrated 2 017212 Gest. Age on Collection Date weeks 18185-9
017170 Integrated 2 017213 Weight lbs 29463-7
017170 Integrated 2 017215 SECOND TRIMESTER SAMPLE N/A
017170 Integrated 2 017216 Collected On 33882-2
017170 Integrated 2 017217 Gestational Age weeks 18185-9
017170 Integrated 2 017218 Weight lbs 29463-7
017170 Integrated 2 017254 Maternal Age at EDD yr 43993-5
017170 Integrated 2 017255 Race 21484-1
017170 Integrated 2 017898 Insulin Dep Diabetes 44877-9
017170 Integrated 2 017256 Number of Fetuses 11878-6
017170 Integrated 2 017257 Nuchal Translucency (NT) mm 12146-7
017170 Integrated 2 017258 Nuchal Translucency MoM 49035-9
017170 Integrated 2 018057 NT Twin B mm 12146-7
017170 Integrated 2 018069 NT MoM Twin B 49035-9
017170 Integrated 2 018175 Additional US N/A
017170 Integrated 2 018224 PAPP-A Value ng/mL 48407-1
017170 Integrated 2 017260 PAPP-A MoM 76348-2
017170 Integrated 2 017262 AFP Value ng/mL 1834-1
017170 Integrated 2 017265 AFP MoM 23811-3
017170 Integrated 2 017266 hCG Value IU/mL 19080-1
017170 Integrated 2 017267 hCG MoM 32166-1
017170 Integrated 2 017268 uE3 Value ng/mL 2250-9
017170 Integrated 2 017269 uE3 MoM 21264-7
017170 Integrated 2 017280 DIA Value pg/mL 23883-2
017170 Integrated 2 017281 DIA MoM 36904-1
017170 Integrated 2 018100 Open Spina Bifida 48803-1
017170 Integrated 2 018101 Down Syndrome 43995-0
017170 Integrated 2 018102 Down Syndrome 49090-4
017170 Integrated 2 018103 Trisomy 18 43994-3
017170 Integrated 2 018104 Trisomy 18 47223-3
017170 Integrated 2 017287 OSB Interpretation 49586-1
017170 Integrated 2 017172 Down Syndrome Interpretation 49586-1
017170 Integrated 2 017289 Trisomy 18 Interpretation 49586-1
017170 Integrated 2 017290 Comments: 77202-0
017170 Integrated 2 017856 Note: N/A
017170 Integrated 2 511933 PDF 11502-2

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