Insulin-like Growth Factor-binding Protein 1 (IGFBP-1) (Endocrine Sciences)

CPT: 83520
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Test Details

Synonyms

  • IGF-binding Protein 1
  • IGFBP-1

Use

Identify women who are at high risk for developing preëclampsia

Methodology

Immunochemiluminometric assay (ICMA)

Additional Information

Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2.1,2 IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium.3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.1 IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes. Type 2 diabetics tend to have low serum IGFBP-1 levels. Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels. Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome. IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation.4,5 The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.6

Specimen Requirements

Specimen

Serum, frozen

Volume

0.5 mL

Minimum Volume

0.1 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

Transfer the serum into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Stability Requirements

Temperature

Period

Room temperature

1 day

Refrigerated

2 days

Frozen

16 months

Freeze/thaw cycles

Stable x6

Causes for Rejection

Plasma specimens

Clinical Information

Footnotes

1. Clemmons DR. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 1997 Mar; 8(1):45-62 (review). 9174662
2. Ranke MB, Elmlinger M. Functional role of insulin-like growth factor binding proteins. Horm Res. 1997; 48(Suppl 4):9-15 (review). 9350439
3. Lee PD, Conover CA, Powell DR. Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 1993 Oct; 204(1):4-29. 7690486
4. Hills FA, Gunn LK, Hardiman P, Thamaratnam S, Chard T. IGFBP-1 in the placenta, membranes and fetal circulation: Levels at term and preterm delivery. Early Hum Dev. 1996 Jan 5; 44(1):71-76. 8821897
5. Hills FA, English J, Chard T. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: Relation to birthweight and maternal weight. J Endocrinol. 1996 Feb; 148(2):303-309. 8699144
6. Grobman WA, Kazer RR. Serum insulin, insulin-like growth factor-I, and insulin-like growth factor binding protein-1 in women who develop pre-eclampsia. Obstet Gynecol. 2001 Apr; 97(4):521-526. 11275021

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
140822 IGF-BP1 140824 IGF Binding Protein 1 ng/mL 12722-5

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