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Insulin-like Growth Factor-binding Protein 1 (IGFBP-1) (Endocrine Sciences)
- IGF-binding Protein 1
Identify women who are at high risk for developing preëclampsia
Immunochemiluminometric assay (ICMA)
Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2.1,2 IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium.3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.1 IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes. Type 2 diabetics tend to have low serum IGFBP-1 levels. Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels. Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome. IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation.4,5 The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.6
0.1 mL (Note: This volume does not allow for repeat testing.)
Transfer the serum into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|140822||IGF-BP1||140824||IGF Binding Protein 1||ng/mL||12722-5|