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Inflammatory Bowel Disease (IBD) Profile
- Crohn's Disease
- Ulcerative Colitis
Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG
Rule out Crohn's disease and ulcerative colitis
Atypical ANCA: indirect fluorescent antibody (IFA); Saccharomyces cerevisiae, IgA, and IgG: enzyme immunoassay (EIA)
• Saccharomyces cerevisiae, IgA: negative: <20.0
• Saccharomyces cerevisiae, IgG: equivocal: 20.1−24.9; positive: ≥25.0
• Atypical antineutrophil cytoplasmic antibodies: negative: <1:20
IgA and IgG antibody testing for S cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis. Nearly 80% of Crohn's disease patients are positive for either IgA or IgG. In ulcerative colitis, <15% are positive for IgG, and <2% are positive for IgA. Fewer than 5% of healthy controls are positive for either IgG or IgA antibody, and no healthy controls had antibody for both. The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.
0.7 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Specimen should be free of bacterial contamination, hemolysis, and lipemia.
Causes for Rejection
Hemolysis; lipemia; bacterial contamination
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|164830||Inflammatory Bowel Disease-IBD||164658||Saccharomyces cerevisiae, IgG||Units||6713-2|
|164830||Inflammatory Bowel Disease-IBD||164659||Saccharomyces cerevisiae, IgA||Units||31032-6|
|164830||Inflammatory Bowel Disease-IBD||162402||Atypical pANCA||titer||49503-6|