Inflammatory Bowel Disease (IBD) Profile

CPT: 86256; 86671(x2)
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Test Details

Synonyms

  • Crohn's Disease
  • IBD
  • Ulcerative Colitis

Test Includes

Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG

Use

Rule out Crohn's disease and ulcerative colitis

Methodology

Atypical ANCA: indirect fluorescent antibody (IFA); Saccharomyces cerevisiae, IgA, and IgG: enzyme immunoassay (EIA)

Reference Interval

Saccharomyces cerevisiae, IgA: negative: <20.0

Saccharomyces cerevisiae, IgG: equivocal: 20.1−24.9; positive: ≥25.0

• Atypical antineutrophil cytoplasmic antibodies: negative: <1:20

Additional Information

IgA and IgG antibody testing for S cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis. Nearly 80% of Crohn's disease patients are positive for either IgA or IgG. In ulcerative colitis, <15% are positive for IgG, and <2% are positive for IgA. Fewer than 5% of healthy controls are positive for either IgG or IgA antibody, and no healthy controls had antibody for both. The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.

Specimen Requirements

Specimen

Serum

Volume

1.5 mL

Minimum Volume

0.7 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Storage Instructions

Refrigerate

Causes for Rejection

Hemolysis; lipemia; bacterial contamination

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164830 Inflammatory Bowel Disease-IBD 164658 Saccharomyces cerevisiae, IgG Units 6713-2
164830 Inflammatory Bowel Disease-IBD 164659 Saccharomyces cerevisiae, IgA Units 31032-6
164830 Inflammatory Bowel Disease-IBD 162402 Atypical pANCA titer 49503-6

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf