Immunoglobulin G, Quantitative, Cerebrospinal Fluid

CPT: 82784
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Test Details

Synonyms

  • Cerebrospinal Fluid IgG
  • CSF IgG
  • CSF Immunoglobulin G
  • IgG, CSF
  • IgG, Quantitative, CSF
  • Immunoglobulin G, CSF

Test Includes

Quantitation of CSF IgG

Use

Evaluate central nervous system involvement by infection, neoplasm, or primary neurologic disease (in particular, multiple sclerosis)

Limitations

Normal levels do not exclude disease; clinical correlation must be applied.

Methodology

Immunologic

Reference Interval

0.0−8.6 mg/dL

Additional Information

Cerebrospinal fluid protein is elevated in many conditions which affect the central nervous system primarily or secondarily. In inflammatory or destructive processes in which serum leaks into CSF, both IgG and albumin will be present in the CSF in increased amounts. Since albumin is not, but immunoglobulins are, synthesized in the central nervous system, a relative increase in CSF IgG indicates presence of a process involving the central nervous system primarily, in particular multiple sclerosis.

IgG showed marked elevation (>16 mg/dL) in 36% of MS patients with only 1% of non-MS controls having this degree of increase. In the slightly elevated category (11% to 16%) however, there was considerable overlap with 38% of MS patients and 27% of non-MS patients falling into this category. While MS patients are maintained on ACTH and/or steroid therapy or during remission, CSF IgG levels decrease but generally remain significantly elevated.

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF)

Volume

0.5 mL

Minimum Volume

0.25 mL

Container

Sterile container

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Excessive blood in CSF

Clinical Information

Special Instructions

The third tube of a routinely obtained three-tube set of CSF should be used for CSF IgG study.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
012211 Immunoglobulin G, Quant, CSF 2464-6 012212 IgG, Quant, CSF mg/dL 2464-6

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