Immunoglobulin G, Quantitative

CPT: 82784
Print Share

Test Details

Synonyms

  • IgG, Serum
  • Quantitative IgG, Serum

Test Includes

Quantitation of IgG

Use

Evaluate humoral immunity; monitor therapy in IgG myeloma; evaluate patients, especially children and those with lymphoma, with propensity to infections

Limitations

If samples containing macroglobulins, cryoglobulins, or cold agglutinins are handled at incorrect temperatures, false low values may result.

Methodology

Immunoturbidimetric

Reference Interval

See table.

Immunoglobulin G, Quantitative

Age (y)

Range (mg/dL)

0 to 1

231−1411

1 to 3

453−916

4 to 6

504−1464

7 to 9

572−1474

10 to 11

698−1560

12 to 13

759−1549

14 to 15

716−1711

16 to 19

549−1584

>19

700−1600

Additional Information

Immunoglobulin G is the major antibody containing protein fraction of blood. With significant decreases in IgG level, on either a congenital or acquired basis, there is an increased susceptibility to infectious processes ordinarily dealt with by humoral antibody (ie, bacterial infection). Thus, patients with repeated infection should have their immunoglobulins, and specifically IgG, measured. Therapy with exogenous γ-globulins may be efficacious in such patients. Conversely, IgG levels will be increased in immunocompetent individuals responding to a wide variety of infections or inflammatory insults (indeed, this represents the basis of the serologic diagnosis of infectious diseases). IgG specific antibody can now be demonstrated for numerous organisms, and when coupled with IgM specific antibody, can give an accurate diagnosis of acute or chronic infection. Today, a major cause for a polyclonal increase in IgG is the acquired immunodeficiency syndrome. Monoclonal IgG can be demonstrated in many cases of multiple myeloma. 3 g/dL of monoclonal IgG is a major diagnostic criterion for myeloma. Oligoclonal IgG can be seen in multiple sclerosis and some chronic hepatitides.

A monoclonal gammopathy may be present when the total IgG value is in the normal range. While many of these patients do not have multiple myeloma, evaluation of these patients for evaluation of the gammopathy and the presence of Bence Jones protein in urine is important.

Specimen Requirements

Specimen

Serum

Volume

1 mL (adult), 0.4 mL (pediatric)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Excessive lipemia

Clinical Information

Special Instructions

Indicate patient's age on the request form.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001776 Immunoglobulin G, Qn, Serum 2465-3 001776 Immunoglobulin G, Qn, Serum mg/dL 2465-3

For Providers

Please login to order a test.

 

© 2018  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf