Immunoglobulin A, Quantitative

CPT: 82784
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Test Details

Synonyms

  • IgA, Serum
  • Quantitative IgA, Serum

Test Includes

Quantitation of IgA

Use

Evaluate humoral immunity; monitor therapy in IgA myeloma

Limitations

If samples containing macroglobulins, cryoglobulins, or cold agglutinins are handled at incorrect temperatures, false low values may result.

Methodology

Immunoturbidimetric

Reference Interval

See table.

Immunoglobulin A, Quantitative

Age

Range (mg/dL)

Male

0 to 10 d

2−362

11 d to 6 m

8−37

7 to 11 m

12−58

1 to 3 y

21−111

4 to 15 y

52−221

16 to 60 y

90−386

>60 y

61−437

Female

0 to 10 d

2−362

11 d to 6 m

8−32

7 to 11 m

11−45

1 to 3 y

19−102

4 to 15 y

51−220

16 to 70 y

87−352

>70 y

64−422

Additional Information

Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially multiple myeloma and “Mediterranean” lymphoma involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease, in ataxia-telangiectasia, or congenitally. Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.

Specimen Requirements

Specimen

Serum

Volume

1 mL (adult), 0.4 mL (pediatric)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Excessive lipemia

Clinical Information

Special Instructions

Indicate the patient's age on the test request form.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001784 Immunoglobulin A, Qn, Serum 2458-8 001784 Immunoglobulin A, Qn, Serum mg/dL 2458-8

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