Immunofixation (IFE) and Protein Electrophoresis, Cerebrospinal Fluid

CPT: 84157; 84166; 86335
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Test Details

Synonyms

  • CSF IEP
  • CSF IFE
  • CSF Immunoelectrophoresis
  • CSF Immunofixation
  • Globulins, CSF
  • IFE/Protein Electrophoresis, CSF

Test Includes

Immunofixation of CSF; CSF protein electrophoresis

Use

Evaluate possible multiple sclerosis, subacute sclerosing panencephalitis, and other chronic CNS disorders associated with local IgG synthesis

Methodology

Agarose gel immunofixation (IFE); protein electrophoresis on agarose media

Reference Interval

Normal pattern

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF)

Volume

5 mL

Minimum Volume

2 mL

Container

Sterile container

Storage Instructions

Refrigerate

Causes for Rejection

Bloody CSF; less than 2 mL CSF

Clinical Information

Special Instructions

The request form should include patient's age and clinical diagnosis.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001438 IFE and PE, CSF 143800 IFE, CSF 13174-8
001438 IFE and PE, CSF 002055 Protein, Total, CSF mg/dL 2880-3
001438 IFE and PE, CSF 143826 Pre-Albumin (CSF) % 13973-3
001438 IFE and PE, CSF 143834 Albumin (CSF) % 13974-1
001438 IFE and PE, CSF 143842 Alpha-1-Globulin (CSF) % 13972-5
001438 IFE and PE, CSF 143859 Alpha-2-Globulin (CSF) % 13975-8
001438 IFE and PE, CSF 143867 Beta Globulin (CSF) % 13976-6
001438 IFE and PE, CSF 143876 Gamma Globulin (CSF) % 13977-4
001438 IFE and PE, CSF 122370 PDF N/A

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf