Human T-Cell Lymphotropic Virus 1, 2 (HTLV-1/HTLV-2), Qualitative

CPT: 86790
Print Share

Test Details

Synonyms

  • HTLV-I/HTLV-II

Test Includes

Qualitative result

Use

Qualitative detection of antibodies to human T-lymphotropic virus, types 1 and/or 2 (HTLV-1/HTLV-2)

Methodology

Chemiluminescent immunoassay (CLIA)

Additional Information

HTLV-1, a human type C retrovirus, is associated with adult T-cell leukemia, tropical spastic paraparesis, and other demyelinating and neoplastic conditions. More recently, HTLV-1 infection has been shown to be associated with T- and B-cell chronic lymphocytic leukemias (CLL), multiple myeloma, some cases of non-Hodgkin lymphoma, polymyositis, arthritis, Kaposi sarcoma, uveitis, strongyloidiasis, and mycosis fungoides. Type 1 HTLV is irregularly distributed throughout the world, as opposed to type 2 virus, which is a new world virus, more common among Americans in North, Central, and South America. HTLV-2 was first isolated from a patient with T-lymphocytic hairy cell leukemia but has not been unequivocally proven to be a pathogen. Recent findings suggest that HTLV-2 may be associated with a number of other leukemias and lymphomas. A high rate of HTLV-2 seropositives has been observed among intravenous drug users. Both HTLV-1 and HTLV-2 are tropic for CD4 lymphocytes and can be transmitted by sexual contact, IV drug use, blood products, transplacentally, and through breast milk.

Specimen Requirements

Specimen

Serum or plasma

Volume

2 mL

Minimum Volume

1.5 mL

Container

Red-top tube or gel-barrier tube or lavender-top (EDTA) tube

Collection

Centrifuge sample to separate serum or plasma. For non−gel-barrier tubes, transfer serum or plasma to a plastic transport tube.

Storage Instructions

Refrigerate. Stable refrigerated for 14 days and frozen for six months.

Causes for Rejection

Bacterial contamination

Clinical Information

References

Blattner WA, Blayney DW, Robert-Guroff M, et al. Epidemiology of human T-cell leukemia/lymphoma virus. J Infect Dis. 1983; 4147(3):406-16. 6300254
Hinuma Y, Komoda H, Chosa T, et al. Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nation-wide seroepidemiologic study. Int J Cancer. 1982; 29(6):631-635. 6980846
Manns A, Blattner WA. The epidemiology of the human T-cell lymphotropic virus type I and type II: Etiologic role in human disease. Transfusion. 1991; 31(1):67-75 (review). 1986467
Poiesz BJ, Ruscetti FW, Gazdar AF, et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980; 77(12):7415-7419. 6261256

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163246 HTLV-I/II Antibodies, Qual 22362-8 163247 HTLV-I/II Antibodies, Qual 29901-6

For Providers

Please login to order a test.

 

© 2018  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf