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Human T-Cell Lymphotropic Virus 1, 2 (HTLV-1/HTLV-2), Qualitative
Qualitative detection of antibodies to human T-lymphotropic virus, types 1 and/or 2 (HTLV-1/HTLV-2)
Chemiluminescent immunoassay (CLIA)
HTLV-1, a human type C retrovirus, is associated with adult T-cell leukemia, tropical spastic paraparesis, and other demyelinating and neoplastic conditions. More recently, HTLV-1 infection has been shown to be associated with T- and B-cell chronic lymphocytic leukemias (CLL), multiple myeloma, some cases of non-Hodgkin lymphoma, polymyositis, arthritis, Kaposi sarcoma, uveitis, strongyloidiasis, and mycosis fungoides. Type 1 HTLV is irregularly distributed throughout the world, as opposed to type 2 virus, which is a new world virus, more common among Americans in North, Central, and South America. HTLV-2 was first isolated from a patient with T-lymphocytic hairy cell leukemia but has not been unequivocally proven to be a pathogen. Recent findings suggest that HTLV-2 may be associated with a number of other leukemias and lymphomas. A high rate of HTLV-2 seropositives has been observed among intravenous drug users. Both HTLV-1 and HTLV-2 are tropic for CD4 lymphocytes and can be transmitted by sexual contact, IV drug use, blood products, transplacentally, and through breast milk.
Serum or plasma
Centrifuge sample to separate serum or plasma. For non−gel-barrier tubes, transfer serum or plasma to a plastic transport tube.
Refrigerate. Stable refrigerated for 14 days and frozen for six months.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|163246||HTLV-I/II Antibodies, Qual||22362-8||163247||HTLV-I/II Antibodies, Qual||29901-6|