Human T-Cell Lymphotropic Virus 1, 2 (HTLV-1/HTLV-2) Differentiation

CPT: 86687; 86688
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Test Details




HTLV-1 infections can be confirmed and differentiated from HTLV-2 infections by using highly purified recombinant proteins or synthetic peptides which are either type common or type specific.


This test is not for screening purposes and should be used as supplementary testing for patients previously identified as reactive for antibodies to HTLV.


Line immunoassay or immunoblot

Specimen Requirements


Serum or plasma


0.5 mL

Minimum Volume

0.25 mL


Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, or yellow-top (ACD) tube

Storage Instructions

Refrigerate or freeze (Pour serum or plasma into plastic pour-off tube before freezing.). Stable 2°C to 8°C for seven days or -20°C for longer storage.

Causes for Rejection

Gross bacterial contamination; hemolysis; lipemia

Clinical Information


Sullivan MT, Williams AE, Fang CT, Grandinetti T, Poiesz BJ, Ehrlich GD. Transmission of human T-lymphotropic virus types I and II by blood transfusion. A retrospective study of recipients of blood components (1983 through 1988). The American Red Cross HTLV-I/II Collaborative Study Group. Arch Intern Med. 1991 Oct; 151(10):2043-2048. 1929693
Zrein M, Louwagie J, Boeykens H, et al. Assessment of a new immunoassay for serological confirmation and discrimination of human T-cell lymphotropic virus infections. Clin Diagn Lab Immunol. 1998 Jan; 5(1):45-49.9455879


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164129 HTLV-I/II Immunoblot 164130 HTLV-I IB 6432-9
164129 HTLV-I/II Immunoblot 164132 HTLV-II IB 26656-9

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