Herpes Simplex Virus (HSV) Types 1/2 Phenotyping for Acyclovir Drug Resistance

CPT: 87252; 87253
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Test Details


  • Acyclovir Resistance HSV (Phenotype)
  • Zovirax® Resistance


This test method uses a plaque reduction assay. It measures the extent to which various concentrations of acyclovir inhibit the growth of virus in cell culture. The concentration of drug which results in a 50% reduction in plaque formation induced by viral cytopathic effect (CPE) versus the no-drug control establishes an inhibitory dose (ID-50) drug concentration reportable value.

Specimen Requirements


Actively-growing isolate (preferred) or eye, genital, oral, urethral, vesicle, or throat swab


One tube with media or one swab


Isolate in tube with media capped tightly; swab in viral transport media

Storage Instructions

Maintain isolate at room temperature. Refrigerate viral transport media with swab.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
138370 HSV Acyclovir Resistance 8-Jan 138371 ID 50 = ug/mL 8-Jan

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