Hepatitis Be Antigen

CPT: 87350
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Test Details


  • HBeAg


The HBe assay is intended for use as an aid in the diagnosis of patients with hepatitis B viral infections, when used in conjunction with results from other HBV marker assays.


Assay performance characteristics have not been established for (1) children younger than 17 years of age, (2) pregnant women, or (3) populations of immunocompromised or immunosuppressed patients.


Immunochemiluminometric assay (ICMA)

Reference Interval


Additional Information

HBeAg appears in acute B hepatitis with or shortly after HBsAg, when the patient is most infectious. HBeAg is found only in HBsAg-positive sera. During the HBeAg-positive state, usually three to six weeks, hepatitis B patients are at increased risk of transmitting the virus to their contacts, including babies born during this period. Exposure to serum or body fluid positive for HBeAg and HBsAg is associated with three to five times greater risk of infectivity than when HBsAg positivity occurs alone. Persistence of HBeAg is associated with chronic liver disease. See figure in Hepatitis B Core Antibody, IgM [016881].

Specimen Requirements


Serum or plasma


1.5 mL

Minimum Volume

0.6 mL (Note: This volume does not allow for repeat testing.)


Gel-barrier tube or lavender-top (EDTA) tube


If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Refrigerate. Samples can be stored at 2°C to 8°C for seven days or at -20°C for one year. Stable for three freeze/thaw cycles.

Causes for Rejection

Non-EDTA plasma specimen; heat-inactivated specimens; cord blood; cadaver specimens; or body fluids other than serum or EDTA plasma

Clinical Information

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.


Edwards MS. Hepatitis B serology−help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). 3287312
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757 (review). 3319367
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. 7315794
Mushahwar IK, McGrath LC, Drnec J, Overby LR. Radioimmunoassay for detection of hepatitis B e antigen and its antibody. Results of clinical evaluation. Am J Clin Pathol. 1981 Nov; 76(5):692-697. 6170222
Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1; 294(14):746-749. 943694


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006619 Hep Be Ag 13954-3 006619 Hep Be Ag 13954-3

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