Hepatitis Be Antibody

CPT: 86707
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Test Details


  • Anti-HBe
  • Antibody to Hepatitis Be Antigen
  • HBeAb


Differential diagnosis, staging, and prognosis of hepatitis B infection


Enzyme immunoassay (EIA)

Reference Interval


Additional Information

The appearance of anti−HBe in patients who have previously been HBeAg positive indicates a reduced risk of infectivity. Failure of appearance implies disease activity and probable chronicity but patients with HBeAb may have chronic hepatitis. Chronic HBsAg carriers can be positive for either HBeAg or anti-HBe, but are less infectious when anti-HBe is present. HBe can persist for years, but usually disappears earlier than anti-HBs or anti-HBc. Anti-HBe has not been found as the sole serologic marker for hepatitis B infection. See figure in Hepatitis B Core Antibody, IgM [016881].

Specimen Requirements


Serum or plasma


1 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube


If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions


Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tube

Clinical Information


Bortolotti F, Calzia R, Cadrobbi P, Crivellaro C, Alberti A, Marazzi MG. Long-term evolution of chronic hepatitis B in children with antibody to hepatitis B e antigen. J Pediatr. 1990 Apr; 116(4):552-555. 2319401
Edwards MS. Hepatitis B serology−help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). 3287312
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. 7315794
Mushahwar IK, McGrath LC, Drnec J, Overby LR. Radioimmunoassay for detection of hepatitis B e antigen and its antibody. Results of clinical evaluation. Am J Clin Pathol. 1981 Nov; 76(5):692-697. 6170222
Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1; 294(14):746-749. 943694


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006635 Hep Be Ab 13953-5 006635 Hep Be Ab 13953-5

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