Hepatitis B Core Antibody, Total

CPT: 86704
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  • Anti-HBc
  • Antibody to Hepatitis B Core Antigen
  • Core Antibody

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Expected Turnaround Time

1 - 2 days

Specimen Requirements


Serum or plasma


1 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube


If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tube

Test Details


Aid in the diagnosis of acute or chronic hepatitis B virus (HBV) infection and in the determination of the clinical status of HBV infected individuals in conjunction with other HBV serological markers. Aid in differential diagnosis of hepatitis. The presence of anti-HBc total antibody indicates previous or ongoing infection with HBV in an undefined time frame.


Immunochemiluminometric assay (ICMA)

Reference Interval



AuBuchon JP, Sandler SG, Fang CT, Dodd RY. American Red Cross experience with routine testing for hepatitis B core antibody. Transfusion. 1989 Mar-Apr; 29(3):230-232. 2493695
Chambers LA, Popovsky MA. Decrease in reported post-transfusion hepatitis. Contributions of donor screening for alanine aminotransferase and antibodies to hepatitis B core antigen and changes in the general population. Arch Intern Med. 1991 Dec; 151(12):2445-2448. 1747001
Edwards MS. Hepatitis B serology—help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). 3287312
Gupta S, Govindarajan S, Fong TL, Redeker AG. Spontaneous reactivation in chronic hepatitis B: patterns and natural history. J Clin Gastroenterol. 1990 Oct; 12(5):562-568. 2230000
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757 (review). 3319367
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. 7315794


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006718 Hep B Core Ab, Tot 13952-7 006718 Hep B Core Ab, Tot 13952-7

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