Hemoglobin (Hb) Solubility With Reflex to Hemoglobin Fractionation, Blood

CPT: 85660. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details

Synonyms

  • Hb Solubility
  • Sickle Cell Preparation
  • Sickle Cell Solubility Test
  • Sickle Cell Test
  • Sickle Prep
  • Sickledex™

Test Includes

Hemoglobin (Hb) solubility and automatic reflex to hemoglobin (Hb) fractionation blood (at additional charge), if positive.

Use

Qualitative determination of presence of hemoglobin S; detect sickling hemoglobins; evaluate hemolytic anemia, undiagnosed hereditary anemia with morphologic (sickle-like) abnormalities on peripheral blood smear

Methodology

Sodium hydrosulfite reduction

Reference Interval

Negative

Additional Information

Specimen Requirements

Specimen

Whole blood

Volume

1 mL

Minimum Volume

0.6 mL

Container

Lavender-top (EDTA) tube; capillary puncture: three microhematocrit tubes. Blue-top (sodium citrate) tube, yellow-top (ACD) tube, or green-top (heparin) tube may also be submitted.

Patient Preparation

No preliminary fluid or food restriction is required.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Specimen other than whole blood received; clotted specimen

Clinical Information

References

Chehab FF, Kan YW. Detection of sickle cell anaemia mutation by colour DNA amplification. Lancet. 1990 Jan 6; 335(8680):15-17. 1967329
Miale JB. Laboratory Medicine: Hematology. 6th ed. St Louis, Mo: Mosby-Year Book Inc;1982:624-625.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
005330 HB Solu + Rflx Frac 6864-3 005224 Hemoglobin (Hgb) Solubility 6864-3
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121706 Hgb F % 4576-5
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121702 Hgb A % 4546-8
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121703 Hgb S % 4625-0
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121704 Hgb C % 4563-3
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121705 Hgb A2 % 34660-1
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121707 Hgb Variant % 42248-5
Reflex Table for Hemoglobin (Hgb) Solubility
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 120880 Hemoglobin Frac.w/o Solubility 121708 Interpretation 12710-0
Reflex 2 000000 121089 000000 12710-0

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