Foscarnet Resistance HSV (Phenotype)

CPT: 87252; 87253
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Synonyms

  • Foscavir® Resistance
  • Herpes Simplex Types 1 and 2 Virus Phenotyping for Foscarnet Drug

Expected Turnaround Time

21 - 24 days


Related Documents


Specimen Requirements


Specimen

Actively-growing isolate (preferred) or eye, genital, oral, urethral, vesicle, or throat swab (from which HSV isolation will be attempted)


Volume

One cell culture tube or one swab in viral transport media


Container

Isolate growing in a permissive cell line (ie MRC-5 or A549) or primary sample in viral transport media (VTM)


Storage Instructions

Maintain isolate at room temperature. Refrigerate viral transport media with swab. Submit as soon as possible, but within five days of collection.


Test Details


Use

This test method uses a plaque reduction assay. It measures the extent to which various concentrations of foscarnet inhibit the growth of virus in cell culture. The concentration of drug which results in a 50% reduction in plaque formation induced by viral cytopathic effect (CPE) versus the no-drug control establishes an inhibitory dose (ID-50) drug concentration reportable value.


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
138362 HSV Foscarnet Resistance 256-8 138363 ID 50 = ug/mL 256-8

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