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FKHR Oncology FISH
- Leukemia FISH
- Lymphoma FISH
Confirmation/identification of cancer-related alterations (alveolar rhabdomyosarcoma)
Fluorescence in situ hybridization (FISH)
A FKHR gene rearrangement is found in alveolar rhabdomyosarcoma (A-RMS). A-RMS is characterized by two pathognomonic translocations which generate gene fusions: t(2;13)(q35;q14) [PAX3-FKHR] and t(1;13)(p36;q14) [PAX7-FKHR], found in 80% and 15% of cases, respectively.
Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.
Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow
Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow
Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze. Sample must arrive in the laboratory within 72 hours of collection.
Maintain specimen at room temperature.
Causes for Rejection
Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen
There will be an additional charge for processing paraffin block samples or for samples that require culture.