FKHR Oncology FISH

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Test Details

Synonyms

  • Leukemia FISH
  • Lymphoma FISH

Use

Confirmation/identification of cancer-related alterations (alveolar rhabdomyosarcoma)

Methodology

Fluorescence in situ hybridization (FISH)

Additional Information

A FKHR gene rearrangement is found in alveolar rhabdomyosarcoma (A-RMS). A-RMS is characterized by two pathognomonic translocations which generate gene fusions: t(2;13)(q35;q14) [PAX3-FKHR] and t(1;13)(p36;q14) [PAX7-FKHR], found in 80% and 15% of cases, respectively.

Specimen Requirements

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Collection

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze. Sample must arrive in the laboratory within 72 hours of collection.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Clinical Information

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510371 FKHR Oncology FISH 510392 Specimen Type 31208-2
510371 FKHR Oncology FISH 510393 Cells Counted N/A
510371 FKHR Oncology FISH 510394 Cells Analyzed N/A
510371 FKHR Oncology FISH 510366 FISH Result 48674-6
510371 FKHR Oncology FISH 510399 Interpretation 50398-7
510371 FKHR Oncology FISH 510367 Director Review: 48672-0
510371 FKHR Oncology FISH 510278 FKHR FISH, Putaway N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf