First Trimester Screen With Nuchal Translucency

CPT: [MAAA: 81509] or 84163; 84702; 86336
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Test Details

Synonyms

  • First Trimester Screening, Combined Test

Test Includes

Dimeric inhibin A (DIA); hCG; pregnancy-associated plasma protein A (PAPP-A)

Use

Screening test in the first trimester of pregnancy for fetal Down syndrome and trisomy 18

Limitations

Screening test for Down syndrome and trisomy 18. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a chromosome abnormality is present. This test does not screen for open neural tube defects.

Methodology

Chemiluminescent immunoassay

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Gel-barrier tube, no thrombin additive

Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Clinical Information

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Client must provide a fetal nuchal translucency (NT) measurement and crown rump length measurement. The NT measurement must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided. The following information must also be provided: patient's weight, patient's date of birth, and the number of fetuses. Also indicate relevant patient history (ie, prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening request form (0900). Serum testing is provided from 10.0 to 13.9 weeks' gestation. NT can be assessed when the CRL is 45 to 84 mm.

References

Wald NJ, Rodeck C, Hackshaw AK, Walters J, Chitty L, Mackinson AM. First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS). J Med Screen 2003; 10(2):56-104.14746340

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017500 First Trimester Screen w/NT 017501 Results N/A
017500 First Trimester Screen w/NT 017502 Test Results: 50679-0
017500 First Trimester Screen w/NT 017503 Crown Rump Length mm 11957-8
017500 First Trimester Screen w/NT 018278 Crown Rump Length Twin B mm 11957-8
017500 First Trimester Screen w/NT 017504 CRL Scan 34970-4
017500 First Trimester Screen w/NT 018279 CRL Scan Twin B 34970-4
017500 First Trimester Screen w/NT 018280 Sonographer ID# 49089-6
017500 First Trimester Screen w/NT 017505 Gest. Age on Collection Date weeks 18185-9
017500 First Trimester Screen w/NT 017506 Maternal Age At EDD years 43993-5
017500 First Trimester Screen w/NT 017507 Race 21484-1
017500 First Trimester Screen w/NT 017508 Weight lbs 29463-7
017500 First Trimester Screen w/NT 018277 Number of Fetuses 11878-6
017500 First Trimester Screen w/NT 017577 Nuchal Translucency mm 12146-7
017500 First Trimester Screen w/NT 017512 Nuchal Translucency MoM 49035-9
017500 First Trimester Screen w/NT 018281 NT Twin B mm 12146-7
017500 First Trimester Screen w/NT 018282 NT MoM Twin B 49035-9
017500 First Trimester Screen w/NT 018178 Additional US N/A
017500 First Trimester Screen w/NT 017513 hCG Value IU/mL 19080-1
017500 First Trimester Screen w/NT 017514 hCG MoM 32166-1
017500 First Trimester Screen w/NT 018216 PAPP-A Value ng/mL 48407-1
017500 First Trimester Screen w/NT 017516 PAPP-A MoM 76348-2
017500 First Trimester Screen w/NT 017535 DIA Value pg/mL 23883-2
017500 First Trimester Screen w/NT 017518 DIA MoM 36904-1
017500 First Trimester Screen w/NT 018079 Down Syndrome 43995-0
017500 First Trimester Screen w/NT 018080 Down Syndrome 49090-4
017500 First Trimester Screen w/NT 018081 Trisomy 18 43994-3
017500 First Trimester Screen w/NT 018082 Trisomy 18 47223-3
017500 First Trimester Screen w/NT 017523 Down Syndrome Interpretation 50679-0
017500 First Trimester Screen w/NT 017524 Trisomy 18 Interpretation 50679-0
017500 First Trimester Screen w/NT 017532 Comments N/A
017500 First Trimester Screen w/NT 018271 Note: N/A
017500 First Trimester Screen w/NT 511933 PDF 80563-0

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