Fibrinogen Evaluation Profile

CPT: 85384; 85385; 85635; 85670
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Test Details

Test Includes

Fibrinogen activity; fibrinogen antigen; thrombin mixing study

Specimen Requirements

Specimen

Plasma, frozen

Volume

6 mL (2 mL in each of three tubes)

Container

Blue-top (sodium citrate) tubes

Patient Preparation

Do not draw from an arm with a heparin lock or heparinized catheter.

Collection

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

Storage Instructions

Freeze.

Clinical Information

Footnotes

1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
336624 Fibrinogen Evaluation Profile 001702 Fibrinogen Activity mg/dL 3255-7
336624 Fibrinogen Evaluation Profile 117051 Fibrinogen Antigen mg/dL 42772-4
336624 Fibrinogen Evaluation Profile 109009 Thrombin Time sec 3243-3
336624 Fibrinogen Evaluation Profile 117181 Reptilase Time sec 6683-7
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117110 TT Mix+TTN 117171 Thrombin Time Mix sec 33525-7
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117110 TT Mix+TTN 117203 Thrombin Neutralization sec 46224-2
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117110 TT Mix+TTN 117171 Thrombin Time Mix sec 33525-7
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117110 TT Mix+TTN 117203 Thrombin Neutralization sec 46224-2

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