Fentanyl and Metabolite

CPT: 80354
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Test Details


Relief of pain adjunct to general or regional anesthesia moderate to moderately-severe pain. Indications for monitoring include the following: to confirm or identify suspected drug toxicity in chronic use, therapeutic misadventure, or accidental or intentional acute overdose; to aid in the identification of an unknown drug ingested in unknown quantities, drug identification and/or quantitation may be performed as an adjunct for patient management; to monitor selected patient groups at greater risk for analgesic drug toxicity or drug-to-drug interaction; to confirm complete drug absorption and adequate drug elimination as an adjunct to overdose management.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Specimen Requirements


Serum, plasma, or whole blood


0.25 mL

Minimum Volume

0.05 mL


Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Separate serum or plasma within two hours of collection and transfer to a plastic transport tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

14 days


14 days


14 days

Causes for Rejection

Gel-barrier tube

Clinical Information


Drug Information Handbook. 24th ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2015; 857-868.
White S, Wong SH. Standards of laboratory practice: Analgesic drug monitoring. National Academy of Clinical Biochemistry. Clin Chem. 1998 May; 44(5):1110-1123. 9590395


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071543 Fentanyl and Metabolite 071539 Fentanyl ng/mL 3636-8
071543 Fentanyl and Metabolite 071541 Norfentanyl ng/mL 11074-2

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