Ethylene Glycol, Serum or Plasma

CPT: 82693
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Special Instructions

This test number is not intended for workplace testing and does not comply with state regulatory workplace testing programs.


Expected Turnaround Time

2 - 4 days


Related Documents


Specimen Requirements


Specimen

Serum or plasma


Volume

1 mL


Minimum Volume

0.2 mL


Container

Red-top tube, green-top (li-heparin) tube, gray-top (sodium fluoride) tube, plasma from lavender-top tube


Collection

Blood is to be collected by venipuncture and mixed immediately by gentle inversion at least six times to ensure adequate mixing. Separate plasma or serum from cells by centrifugation in less than two hours.


Storage Instructions

Refrigerate.


Stability Requirements

Temperature

Period

Room temperature

8 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles:

Stable x2


Test Details


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Reference Interval

None detected (<5 mg/dL)


Critical Value

Potentially toxic: >20 mg/dL

Additional Information

Ethylene glycol is a colorless, odorless, sweet tasting compound used commercially in antifreeze. It has been utilized in suicide attempts, as a substitute for ethanol and in accidental poisonings in both children and domestic pets. 100 mL is lethal; rapid treatment can prevent damage. Half-life is three to five hours. Toxicity is manifested by CNS depression (1 to 12 hours after ingestion), cardiopulmonary symptoms (12 to 24 hours after ingestion), and renal damage (24 to 72 hours after ingestion). Oxalate is a minor metabolite of ethylene glycol and crystals are commonly seen in urine. In addition to blood levels of ethylene glycol, hypocalcemia, elevated anion gap, metabolic acidosis, and osmolal gap elevation are observed. Precaution: Toxicity may be manifested without osmolal gap changes and osmolal and anion gap increases can be present with very low levels of ethylene glycol.


References

Fraser AD. Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning. Ther Drug Monit. 2002 Apr; 24(2):232-238. 11897969

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071654 Ethylene Glycol, Serum 5646-5 071654 Ethylene Glycol, Serum mg/dL 5646-5

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