Estrone

CPT: 82679
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Test Details

Synonyms

  • E1

Use

Evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.

Methodology

Radioimmunoassay (RIA)

Reference Interval

See table.1-2

Age (y)

Male (pg/mL)

Female (pg/mL)

Tanner Stage I

5−17

4−29

Tanner Stage II

10−25

10−33

Tanner Stage III

15−25

15−43

Tanner Stage IV

15−45

16−77

Tanner Stage V

20−45

29−105

Adults

15−65

Follicular phase: 39−132

Periovulatory: 58−256

Luteal phase: 54−179

Pregnancy

1st trimester: 247−2774

2nd trimester: 569−5781

Postmenopausal

with ERT: 51−488

without ERT: 31−100

Specimen Requirements

Specimen

Serum or plasma

Volume

0.8 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube

Patient Preparation

No isotopes administered 24 hours prior to venipuncture.

Collection

If a red-top tube or lavender-top tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Refrigerate

Causes for Rejection

Gross hemolysis; recently administered radioisotopes; lipemia; icteric specimen

Clinical Information

Special Instructions

Nonpregnant patients only.

Footnotes

1. Tietz NW, ed. Clinical Guide to Laboratory Tests. 4th ed. Philadelphia, Pa: WB Saunders Co; 2006:378-379.
2. Estrone RIA DSL8700-FOC-02 [package insert]. Beckman Coulter/ImmunoTech; 2018.

References

Kronenberg H, Williams HR. The physiology and pathology of the female reporductive axis. In: Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders/Elsevier; 2008:541-614.
Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med. 2002 Jan 31;346(5):340-352.11821512

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004564 Estrone, Serum 2258-2 004564 Estrone, Serum pg/mL 2258-2

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