Estrogens, Total

CPT: 82672
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Test Details

Use

Evaluate for ovarian estrogen producing tumor in the premenarcheal and postmenopausal female; evaluate estrogen excess in males. Estrogen analysis may be helpful in establishing time of ovulation and optimal time for conception. Serial samples must be collected over several days to evaluate baseline and peak total estrogen levels.

Methodology

Radioimmunoassay (RIA)

Reference Interval

See table.1

Age

Male (pg/mL)

Female (pg/mL)

Prepubertal

<40

<40

Adults

40−115

Female cycle:

Castrate: <40

1 to 10 d: 61−394

11 to 20 d: 122−437

21 to 30 d: 156−350

Postmenopausal: <40

HMG treatment for ovulation induction: 400−800

Tanner Stage

I

10−38

10−46

II

17−45

22−63

III

22−55

24−110

IV

27−80

40−180

V

25−80

60−280

Specimen Requirements

Specimen

Serum or plasma

Volume

2.8 mL

Minimum Volume

2.2 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube, gel-barrier tube, or green-top (heparin) tube

Patient Preparation

Patient must avoid having radioisotope scan prior to collection of specimen.

Collection

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Refrigerate

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

7 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; recent isotopic scan; gross lipemia; icteric specimen

Clinical Information

Footnotes

1. Tietz NW, ed. Clinical Guide to Laboratory Tests. 3rd ed. Philadelphia, Pa: WB Saunders Co;1995:220.

References

Ashby CD, Danzer HC, Swerdloff RS, et al. Estrogen radioimmunoassay suitable for the monitoring of ovulation induction. Clin Chem. 1980; 26(8):1143-1146. 7389084
Marshall JR. Induction of ovulation. Clin Obstet Gynecol. 1978; 21(1):147-162 (review). 343954
Taymor ML, Yussman MA, Gminski D, et al. Estrogen monitoring in ovulation induction. Fertil Steril. 1970; 21(11):759-762.5474219

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004549 Estrogens, Total 2254-1 004549 Estrogens, Total pg/mL 2254-1

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