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Estrogen Receptor/Progesterone Receptor (ER/PR), Immunohistochemical, Paraffin Block
- ER/PR Assay
- ER/PR, IHC, Paraffin Block
Estrogen receptor analysis; progesterone receptor analysis
Cancer prognosis: ER and PR positivity is a favorable prognostic factor in breast and endometrial carcinoma and meningioma.
Response to endocrine therapy: Combined ER and PR positivity is associated with increased response to antiestrogen therapies.
In the absence of internal positive control staining, a false-negative result cannot be excluded. The presence or absence of positive internal control staining is indicated on all negative reports. Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.
Immunohistochemistry (IHC). This is a semiquantitative measurement of ER/PR positive tumor nuclei in stained histologic tissue sections.
Estrogen receptors (ER) are cellular proteins that bind estrogens with a high affinity and specificity. They are a necessary component for estrogen-mediated cellular activity. The presence of progesterone receptors (PR) demonstrates an active ER mechanism for the induction of PR expression. Immunohistochemical staining permits the detection and localization of ER/PR within sections from formalin-fixed, paraffin-embedded tissue.
Clinical utilities for the measurement of ER/PR include patient prognosis and patient response to adjuvant endocrine therapy. Individuals with receptor-positive tumors generally have a better prognosis, as indicated by a longer interval to disease recurrence and a longer overall survival, than patients with receptor-negative tumors. Studies have also shown that the determination of receptor status by immunohistochemistry may be useful in predicting patient response to hormonal therapy.
Formalin-fixed, paraffin-embedded (FFPE) tumor
One paraffin block or seven unstained, positively-charged tissue slides cut at 4 to 5 microns and dried for one hour at 60°C
Specimen should be fixed in 10% neutral-buffered formalin within one hour of collection. Optimum fixation time is six to 72 hours.
Maintain specimen at room temperature.
Please direct any questions regarding this test to oncology customer service at 800-345-4363.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|480277||ER/PR,Immunohistochem,Paraffin||480278||Estrogen Receptor IHC||%||14228-1|
|480277||ER/PR,Immunohistochem,Paraffin||480279||Progesterone Rec. IHC||%||14230-7|