Epstein-Barr Virus (EBV) Nuclear Antigen Antibodies, IgG

CPT: 86664
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Synonyms

  • EBV Nuclear Antigen, IgG Antibodies
  • EBV-NA, EBNA Antibodies

Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

0.5 mL


Minimum Volume

0.2 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x4


Causes for Rejection

Hemolysis; lipemia; grossly icteric; visible particulate matter; gross bacterial contamination


Test Details


Use

Aid in the diagnosis of EBV infections (infectious mononucleosis). EBV nuclear antigen (EBNA) IgG antibodies do not appear during the acute phase of infection but appear around 2-4 months after initial clinical presentation and typically persist for life. The presence of EBNA IgG antibodies in healthy individuals typically indicates past immunological exposure to EBV; however, false positive results can occur. Additionally, approximately 5-10% of individuals infected with EBV never develop EBNA IgG antibodies. Because of the complex relationship that exists between the EBV virus/host reaction and clinical manifestation, tracking of EBV antibody patterns may assist in diagnosis of EBV infection. Individual levels of specific antibodies are not necessarily indicative of disease state but can be of diagnostic significance when tracked as an antibody response profile. Antibody response profiles for the different EBV antigens demonstrate a characteristic pattern for silent primary or persistent latent EBV infections, as well as for each of the EBV-associated disease.


Limitations

The results for this test are not by themselves diagnostic and should be considered in association with other clinical data and patient symptoms.

This test is intended for qualitative determination only. The numeric value of the final result above the cutoff is not indicative of the amount of EBNA antibody.


Methodology

Chemiluminescent immunoassay (CLIA)


Reference Interval

• Negative: <18.0 U/mL

• Equivocal: 18.0−21.9 U/mL

• Positive: >21.9 U/mL


Additional Information

Set up and reported Monday thru Friday.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
010272 EBV Nuclear Antigen Ab, IgG 30083-0 010276 EBV Nuclear Antigen Ab, IgG U/mL 30083-0

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