DNA Ploidy Analysis, Paraffin Block

CPT: 88182
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Test Details

Synonyms

  • DNA Histogram, Paraffin

Test Includes

DNA index; histogram interpretation

Use

Cancer prognosis. In general, aneuploid tumors have an unfavorable prognosis compared to diploid tumors.

Limitations

Use of fixatives other than formalin may not yield equivalent or satisfactory results. No % S phase is reported for tumors analyzed by image cytometry. Small biopsies require image analysis of a 6-μ tissue section. This test is not a diagnostic test for cancer.

Methodology

Flow cytometry

Additional Information

The DNA index is a measure of the nuclear DNA content of tumor cells compared to normal cells. Tumors with abnormal DNA content are termed DNA aneuploid while those with DNA content equal to normal cells are termed DNA diploid.

Specimen Requirements

Specimen

Formalin-fixed, paraffin-embedded (FFPE) tumor (tissue block)

Volume

One paraffin block

Container

Paraffin block transport pouch

Collection

Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.

Storage Instructions

Maintain specimen at room temperature.

Clinical Information

Special Instructions

Please direct any questions regarding this test to oncology customer service at 800-345-4363.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
480327 DNA Ploidy, Paraffin Block 487018 Tissue Site N/A
480327 DNA Ploidy, Paraffin Block 487002 Specimen Received N/A
480327 DNA Ploidy, Paraffin Block 487003 Method of Analysis N/A
480327 DNA Ploidy, Paraffin Block 487004 DNA Index (Population 1) 30912-0
480327 DNA Ploidy, Paraffin Block 487017 S Phase Interpretation N/A
480327 DNA Ploidy, Paraffin Block 487012 Ploidy Interpretation N/A
480327 DNA Ploidy, Paraffin Block 487026 Director Review 72486-4
480327 DNA Ploidy, Paraffin Block 483014 DNAPff N/A

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf