Dihydrotestosterone (DHT) (Endocrine Sciences)

CPT: 80327
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Test Details

Synonyms

  • Androstaner-3-one
  • DHT
  • Hydroxy-5α

Use

Dihydrotestosterone and dihydrotestosterone/ratio may be used for differential diagnosis of diseases of sexual differentiation (DSD). DHT levels may be inappropriately low compared to testosterone levels in 5a-reductase deficiency. It is recommended by guidelines to measure the ratio of testosterone to DHT.

DHT levels may also be monitored to follow the effectiveness of 5a-reductase inhibitor tesatment in female alopecia.

Methodology

High-pressure liquid chromatography (HPLC) with tandem mass spectrometry

Specimen Requirements

Specimen

Serum (preferred) or plasma, frozen

Volume

1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube, gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube

Collection

Separate serum or plasma from cells within one hour of collection. Send serum or plasma in plastic transport tube. Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

7 days

Frozen

19 months

Freeze/thaw cycles

Stable x6

Clinical Information

References

Douglas G, Axelrad ME, Brandt ML, et.al. Guidelines for Evaluating and Managing Children Born with Disorders of Sexual Development. Pediatr Ann. 2012 Apr:41(4):e1-e7.22494213
Goodman NF, Cobin RH, Futterweit W, et. al. Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome--Part 1. Endocr Pract. 2015 Nov;21(11):1291-1300.26509855
Hughes IA, Houk C, Ahmed SF, Lee PA; LWPES Consensus Group; ESPE Consensus Group. Consensus statement on management of intersex disorders. Arch Dis Child. 2006 Jul;91(7):554-563.16624884
Ocal G. Current Concepts in Disorders of Sexual Development. J Clin Res Pediatr Endocrinol. 2011;3(3):105-114.21911322

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500142 Dihydrotestosterone 500143 Dihydrotestosterone ng/dL 1848-1

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