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Diabetes autoantibodies assessment is helpful in identifying and managing patients at risk for development of type 1 diabetes. Published positivity rates for diabetes autoantibodies in new-onset type 1 diabetes patients listed below are based on the combined analysis of GAD-65, ICA 512, insulin antibodies, and ZnT8 antibodies. The combined analysis has a 98% autoimmunity detection rate, with 1.8% diabetic individuals remaining as autoantibody-negative. fewer than 3% of type 2 diabetics have positive antibodies.1
Positive rate in new-onset type 1 diabetes patients:
• GAD-65 antibodies = 68% positive
• ICA 512 antibodies = 72% positive
• Insulin antibodies = 55% positive
• ZnT8 antibodies = 63% positive
An increase in the number of positive antibodies is associated with a higher likelihood of type 1 diabetes.
Enzyme-linked immunosorbent assay (ELISA), radioimmunoprecipitation
1.0 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.
Freeze. Stable at room temperature or refrigerated for one day. Stable frozen for seven days. Freeze/thaw cycles: stable x3.
Causes for Rejection
Gross hemolysis; lipemic specimen; EDTA plasma
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|504050||Diabetes Autoimmune Profile||141600||Insulin Antibodies||uU/mL||8072-1|
|504050||Diabetes Autoimmune Profile||500610||Anti GAD 65 Antibodies||U/mL||56540-8|
|504050||Diabetes Autoimmune Profile||141533||IA-2 Autoantibodies||U/mL||31209-0|
|504050||Diabetes Autoimmune Profile||504017||ZNT8 Antibodies||U/mL||76651-9|
|504050||Diabetes Autoimmune Profile||504004||Type 1 Diabetes Interpretation||8251-1|