CPT: 82634
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Test Details


  • 11-Desoxycortisol
  • Compound S for Metyrapone Test


Evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve


Liquid chromatography/tandem mass spectrometry (LC/MS-MS) after chromatography and solvent extraction

Additional Information

11-Deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol. The conversion of 11-deoxycortisol to cortisol is inhibited by metyrapone, which acts on 11-β-hydroxylase. The metyrapone test (see the online Endocrine Appendix: ACTH Stimulation) serves as a reliable and sensitive indicator of pituitary ACTH secretory reserve. The 11-deoxycortisol levels normally increase to 100 times the control value following metyrapone administration. Reduced response occurs in patients with hypoadrenalism or with hypopituitarism and in some patients with diseases of the hypothalamus. Patients with myxedema, some pregnant patients, and those on oral contraceptives respond poorly.

Specimen Requirements


Serum, frozen


0.5 mL

Minimum Volume

0.2 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube

Patient Preparation

No isotopes administered 24 hours prior to venipuncture


Transfer the serum into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Stability Requirements



Room temperature

1 day


1 day


2 years

Freeze/thaw cycles

Stable x3

Causes for Rejection

Recently administered isotopes

Clinical Information


Sindler BH, Griffing GT, Melby JC, et al. The superiority of the metyrapone test versus the high-dose dexamethasone test in the differential diagnosis of Cushing's syndrome. Am J Med. 1983 Apr; 74(4):657-662. 6837591
Spark RF. Simplified assessment of pituitary-adrenal reserve: Measurement of serum 11-deoxycortisol after metyrapone. Ann Intern Med. 1971 Nov; 75(5):717-723.4330677


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500550 11-Desoxycortisol 500551 Desoxycortisol(Compound S),S ug/dL 1657-6

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