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Dehydroepiandrosterone (DHEA), ACTH Stimulation
- Dehydroepiandrosterone (Two Specimens)
- DHEA, ACTH Stimulation
- Unconjugated DHEA (Two Specimens)
Evaluate adrenal carcinomas that frequently secrete large amounts of DHEA. Dehydroepiandrosterone (DHEA) is a steroid that is produced by both the adrenal cortex and testis.1 The levels of this steroid increase before the onset of puberty (adrenarche) and decrease significantly with age.2,3 DHEA and DHEA-S are the major precursors of 17-ketosteroids.
Liquid chromatography tandem/mass spectrometry (LC/MS-MS)
1 mL (each specimen)
0.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
If a red-top tube is used, transfer separated serum to a plastic transport tube. Note: Label each tube with the patient's name, collection time, and date. Submit specimens simultaneously on the same test request form.
Draw blood for baseline DHEA. Inject cosyntropin 250 μg IM or IV (if IV, dilute cosyntropin in 2 to 5 mL of sterile saline and inject over two minutes). Draw blood for stimulated DHEA 60 minutes after. See the online Endocrine Appendix: ACTH Stimulation for expected values for various steroids at baseline and after ACTH stimulation.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|140768||DHEA, ACTH Stimulation||140769||DHEA Baseline||ng/dL||16734-6|
|140768||DHEA, ACTH Stimulation||140770||DHEA Stimulated||ng/dL||13863-6|