Dehydroepiandrosterone (DHEA)

CPT: 82626
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Test Details

Synonyms

  • DHEA
  • Unconjugated DHEA

Use

Evaluate adrenal carcinomas that frequently secrete large amounts of DHEA

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

See table.1,2

Age (y)

Range (ng/dL)

0 to 5

0−67

6 to 7

0−110

8 to 10

0−185

11 to 12

0−201

13 to 14

0−318

15 to 16

39−481

17 to 19

40−491

>19

31−701

Additional Information

Dehydroepiandrosterone (DHEA) is a steroid that is produced by both the adrenal cortex and the testis.3 The levels of this steroid increase before the onset of puberty (adrenarche) and decrease significantly with age.4 DHEA and DHEA-S are the major precursors of 17-ketosteroids.

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Storage Instructions

Refrigerate

Stability Requirements

Temperature

Period

Room temperature

6 hours

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Footnotes

1. Ducharme JR, Forest MG, De Peretti E, et al. Plasma adrenal and gonadal sex steroids in human pubertal development. J Clin Endocrinol Metab. 1976; 42(3):468-476. 130382
2. Tietz NW, ed. Clinical Guide to Laboratory Tests. 3rd ed. Philadelphia, Pa: WB Saunders Co;1995:195-196.
3. de Peretti E, Forest M. Unconjugated dehydroepiandrosterone plasma levels in normal subjects from birth to adolescence in humans: The use of a sensitive radioimmunoassay. J Clin Endocrinol Metab. 1976; 43(5):982-991. 186482
4. Carlstrom K, Brady S, Lunell NO, et al. Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: Differences related to age and sex. Maturitas. 1988; 10(4):297-306.2976116

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004100 DHEA, Serum 2193-1 004102 Dehydroepiandrosterone (DHEA) ng/dL 2193-1
Reflex Table for Dehydroepiandrosterone (DHEA)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 123246 Disclaimer: 123246 Disclaimer: N/A

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