Cytomegalovirus (CMV) Antibodies, IgG

CPT: 86644
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Test Details

Use

Aid in the determination of serological status to CMV. IgG antibodies rise gradually and persist for the rest of an individual's life. The specific IgG assay is useful in distinguishing who has been exposed to the virus from those who have not. Levels of IgM to hCMV usually increase for some weeks and decrease slowly thereafter, in four to six months. Occasionally, IgM may circulate for years. For the IgM assay, see Cytomegalovirus (CMV) Antibodies, Quantitative, IgM [096727].

Limitations

Most adults are infected with CMV and it is normal to be a carrier of the virus.

Methodology

Chemiluminescent immunoassay (CLIA)

Reference Interval

• Negative: <0.60 U/mL

• Equivocal: 0.60−0.69 U/mL

• Positive: >0.69 U/mL

Additional Information

CMV causes an infectious mononucleosis syndrome clinically indistinguishable from heterophil positive mononucleosis. Signs include fever, malaise, and increased transaminase levels without jaundice.

Specimen Requirements

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.2 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x4

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Clinical Information

Special Instructions

Identify specimen as acute or convalescent. Acute and convalescent specimens must be submitted on separate test request forms.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006494 Cytomegalovirus (CMV) Ab, IgG 5124-3 006499 Cytomegalovirus (CMV) Ab, IgG U/mL 5124-3

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