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Creatinine, serum; eGFR calculation
Expected Turnaround Time
Within 1 day
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Serum (preferred) or plasma
Gel-barrier tube, red-top tube, green-top (heparin) tube, or lavender-top (EDTA) tube
Separate serum or plasma from cells within 45 minutes of collection.
Maintain specimen at room temperature.1
Causes for Rejection
Hemolysis; improper labeling
A renal function test used in eGFR calculation.2
High creatinine: Renal diseases and insufficiency with decreased glomerular filtration, urinary tract obstruction, reduced renal blood flow including congestive heart failure, shock, and dehydration; rhabdomyolysis can cause elevated serum creatinine. Low creatinine: Small stature, debilitation, decreased muscle mass; some complex cases of severe hepatic disease can cause low serum creatinine levels. In advanced liver disease, low creatinine may result from decreased hepatic production of creatinine and inadequate dietary protein as well as reduced muscle mass.3
With reduced renal blood flow, creatinine rises less quickly than urea nitrogen. Concentration of creatinine only becomes abnormal when about half or more of the nephrons have stopped functioning in chronic progressive renal disease. Antibiotics containing cephalosporin lead to significant false-positive values if samples are drawn within four hours of a dose.4 With severe renal disease, creatinine is not reliable in the presence of cefoxitin therapy. There is less interference reported from the cephalosporins cephalothin, cephaloridine, cephadrine sodium, and cephaloglycin dihydrate. Lipemia, hemolysis, and bilirubin may interfere.5,6
Interfering Endogenous Substances7
Degree of Interference
Ascorbic acid (serum/plasma)
*LabCorp internal studies.
2 to 11 m
1 to <3 y
3 to <5 y
5 to <7 y
7 to <9 y
9 to <11 y
11 to <13 y
13 to <15 y
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|001370||Creatinine||2160-0||100791||eGFR If NonAfricn Am||mL/min/1.73||88294-4|
|001370||Creatinine||2160-0||100797||eGFR If Africn Am||mL/min/1.73||88293-6|